DIMACS Workshop on Protein Structure and Function
November 19, 1999
10:00am - 5:30pm
DIMACS Center, Rutgers University, Piscataway, NJ
- Organizers:
- Israel M. Gelfand, Rutgers University
Presented under the auspices of the Special Year on Mathematical Support for Molecular Biology.
The goal of the workshop is to discuss the problems the structural genomics:
to classify the protein sequences and accurately predict its three-dimensional
structures. In this workshop we will discussed a broad specter of different
methods of analysis of the relationship between sequences, secondary
structures, three-dimensional structures and protein functions. A. Finkelstein
will present and analyze the results of several new approaches to the problem
of finding the folding nucleus in a given 3D protein structure. R. Russell will
describe the problem of Predicting Function from Protein Structure Comparison.
Functional insights is based on the comparison a protein with known structure,
but of unknown function with other proteins of known structure. C. Chothia will
show how the major transitions in the evolution from prokaryotes to vertebrates
affect on protein repertoires. The analysis of 19 genomes revealed that the
duplications of pre-existing genes, their divergence and recombination have an
important role in the large increases in protein repertoires. A. Gutin suggests
computationally exact solutions in several cases for the reconstruction of
inheritance pattern in large human pedigrees using information from many
genetic markers. E. Koonin will discuss the methods for recognition
transcription regulation sites (operators). The approach to this problem based
on simultaneous analysis of several related genomes. I.Gelfand and A. Kister
will discuss what is common to highly non-homologous proteins with
Immunoglobulin-like fold.
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Document last modified on April 13, 1998.