Presented under the auspices of the DIMACS/BioMaPS/MB Center Special Focus on Information Processing in Biology.
This special focus is jointly sponsored by the Center for Discrete Mathematics and Theoretical Computer Science (DIMACS), and the Biological, Mathematical, and Physical Sciences Interfaces Institute for Quantitative Biology (BioMaPS). The National Institutes of Health provides partial funding of the BioMaPS Summer School through the NIH Roadmap for Medical Research, Grant 5 K07 GM72919.
June 9, 2008: Chromatin structure and genomic studies of chromatin Session Chair: Vincent Pirrotta Morning: 9:20 - 9:30 Introduction and welcoming remarks Alexandre Morozov & Vasily Studitsky 9:30 - 10:30 Transcriptional regulatory mechanisms and epigenetic inheritance Kevin Struhl, KEYNOTE SPEAKER, Harvard Medical School 10:30 - 12:00 Intra- and inter-nucleosome interactions of the core histone tail domains Jeff Hayes, University of Rochester Medical Center 12:00 - 1:30 Lunch Break Afternoon: 1:30 - 2:30 Polycomb mechanisms and genomic programming Vincent Pirrotta, Rutgers University 2:30 - 3:30 Organization of chromatin and the transcription machinery throughout the yeast and fly genomes Frank Pugh, Penn State University 3:30 - 3:45 Break 3:45 - 4:45 Chromatin-mediated mechanisms for the regulation of genome accessibility in yeast, worms, and humans Jason Lieb, University of North Carolina, Chapel Hill June 10, 2008: Computational modeling of chromatin states Session Chair: Wilma Olson Morning: 9:30 - 10:00 Introduction to the polymer physics of chromatin Swagatam Mukhopadhyay, Rutgers University 10:00 - 11:00 Epigenetic chromatin silencing Anirvan Sengupta, Rutgers University 11:00 - 12:00 Flexing and Folding of nucleosome-bound DNA Wilma Olson & Guohui Zheng, Rutgers University 12:00 - 1:30 Lunch Break Afternoon: 1:30 - 2:30 Biophysical models of chromatin structure and gene regulation Alexandre Morozov, Rutgers University 2:30 - 3:30 A new model for the linker histone binding based on comparative sequence analysis of chicken and yeast nucleosomal DNA Victor Zhurkin, NIH 3:30 - 3:45 Break 3:45 - 4:45 Prediction of nucleosome positions Guocheng Yuan, Harvard School of Public Health June 11, 2008: Histone modifications and signaling Session Chair: Sergei Grigoryev Morning: 9:30 - 11:00 Inter-nucleosome interactions in chromatin higher-order packing Sergei Grigoryev, Penn State University College of Medicine 11:00 - 12:00 The SAGA of Histone Modifications Patrick Grant, University of Virginia 12:00 - 1:30 Lunch Break Afternoon: 1:30 - 2:30 Diversity in Chromatin Docking Interactions of Chromodomains Sepideh Khorasanizadeh, University of Virginia 2:30 - 3:30 Mix and Match: Landscaping Chromatin during Transcription Thomas Kusch, Rutgers University 3:30 - 5:30 Poster Session June 12, 2008: Chromatin remodeling and transitions Session Chair: David Clark Morning: 9:30 - 11:00 Gene Activation in Yeast: Chromatin Remodeling and Nucleosome Dynamics David Clark, NIH 11:00 - 12:00 Mechanism of nucleosome survival and chromatin remodeling during transcription by Pol II Vasily Studitsky, UMDNJ 12:00 - 1:30 Lunch Break Afternoon: 1:30 - 2:30 Mechanism of ATP-dependent chromatin remodeling: lessons from ISW2 and SWI/SNF Blaine Bartholomew, Southern Illinois University School of Medicine 2:30 - 3:30 Histone Modification, Deposition, and Turnover Paul Kaufman, University of Massachusetts Medical School 3:30 - 3:45 Break 3:45 - 4:45 Functional importance of Histone H4K20 methylation Ruth Steward, Rutgers University June 13, 2008: Programming functional chromatin states Session Chair: Gary Felsenfeld Morning: 9:30 - 10:30 The establishment and maintenance of chromatin boundaries Gary Felsenfeld, NIH 10:30 - 10:45 Break 10:45 - 11:45 The Rise and Fall of Models for Heterochromatin Establishment Marc Gartenberg, UMDNJ 11:45 - 12:45 ATP-dependent chromatin assembly Dmitry Fyodorov, Albert Einstein College of Medicine Afternoon: 12:45 - 1:00 Closing Remarks Alexandre Morozov & Vasily Studitsky: Closing Remarks